Enters the Room

SUMO enters the ring

By the mid-1990s, it was clear that conjugation to ubiquitin could affect not just a protein’s stability, but also its localization and activity. Whether there were other proteins in the cell that could also be covalently linked to substrates in order to regulate their function was unknown, at least until Matunis et al. (1), along with several other groups (2–6), identified the protein that wou...

The GPU Enters Computing's Mainstream

Europe Enters the Eighties

Mathematics Enters the Picture

Can one of the most important Italian Renaissance frescoes reduced in hundreds of thousand fragments by a bombing during the Second World War be re-composed after more than 60 years from its damage? Can we reconstruct the missing parts and can we say something about their original color? In this short paper we want to exemplify, hopefully effectively by taking advantage of the seduction of art,...

C/EBPα enters the nucleolus.

Cell growth, in terms of increase in cell mass, is a prerequisite for cell division. If cells would not grow before they divide, their progeny would become smaller and smaller. As most of the cell's dry mass consists of protein, a high protein biosynthesis rate and therefore a high ribosome production rate are required in rapidly growing cells. The rate-limiting step in ribosomal biogenesis is ...